| Eleven Wonders | VS | Asante Kotoko SC | March 19 2022, 15:00 | |
| Asante Kotoko SC | VS | Karela FC | March 30 2022, 15:00 | |
| King Faisal Babies | VS | Asante Kotoko SC | March 31 2022, 15:00 | |
| Asante Kotoko SC | VS | Hearts of Oak SC | April 07 2022, 15:00 | |
| Real Tamale United | VS | Asante Kotoko SC | April 13 2022, 15:00 | |
| Ashanti Gold SC | VS | Asante Kotoko SC | May 12 2022, 15:00 |
