| Asante Kotoko FC | VS | Bechem United FC | November 07 2021, 16:00 | |
| Bibiani Gold Stars FC | VS | Asante Kotoko FC | November 12 2021, 15:00 | |
| Legon Cities FC | VS | Asante Kotoko FC | November 18 2021, 15:00 | |
| Asante Kotoko FC | VS | Eleven Wonders | November 20 2021, 15:00 | |
| Karela FC | VS | Asante Kotoko FC | November 27 2021, 15:00 | |
| Asante Kotoko FC | VS | King Faisal Babies | December 04 2021, 15:00 | |
| Hearts of Oak SC | VS | Asante Kotoko FC | December 11 2021, 15:00 | |
| Asante Kotoko FC | VS | Real Tamale United | December 15 2021, 15:00 | |
| Asante Kotoko FC | VS | West Africa Football Academy | December 25 2021, 15:45 | |
| Aduana Stars FC | VS | Asante Kotoko FC | January 01 2022, 15:00 | |
| Asante Kotoko FC | VS | Ashanti Gold Sporting Club | January 08 2022, 15:00 | |
| Berekum Chelsea FC | VS | Asante Kotoko FC | January 15 2022, 15:00 | |
| Asante Kotoko FC | VS | Medeama SC | January 22 2022, 15:00 | |
| Asante Kotoko FC | VS | Accra Great Olympics | January 29 2022, 15:00 | |
| Elmina Sharks FC | VS | Asante Kotoko FC | February 05 2022, 15:00 | |
| Asante Kotoko FC | VS | Accra Lions FC | February 12 2022, 15:00 | |
| Asante Kotoko FC | VS | Dreams FC | February 26 2022, 15:00 | |
| Bechem United FC | VS | Asante Kotoko FC | March 05 2022, 15:00 | |
| Asante Kotoko FC | VS | Bibiani Gold Stars FC | March 12 2022, 15:00 | |
| Eleven Wonders | VS | Asante Kotoko FC | March 19 2022, 15:00 |
